{"id":31,"date":"2010-02-04T16:37:28","date_gmt":"2010-02-04T16:37:28","guid":{"rendered":"http:\/\/blogs.dickinson.edu\/sciencenews\/?p=31"},"modified":"2010-02-04T16:43:09","modified_gmt":"2010-02-04T16:43:09","slug":"old-chinese-medicine-new-cancer-treatment","status":"publish","type":"post","link":"https:\/\/blogs.dickinson.edu\/sciencenews\/2010\/02\/04\/old-chinese-medicine-new-cancer-treatment\/","title":{"rendered":"Old Chinese Medicine, New Cancer Treatment"},"content":{"rendered":"

Sara Braniecki<\/p>\n

\u00a0\u00a0 \u00a0Dr. Ahmed Chadli and fellow researchers at the Medical College of Georgia believe that they are on the right track to finding a new cancer treatment using celastrol, a plant derivative derived from trees and shrubs called celastracaea that the Chinese have used to treat symptoms such as fever, chills, and inflammation for centuries.<\/p>\n

\u00a0\u00a0 \u00a0Dr. Chadli and his colleagues think that they can devise a way for celastrol to be used for cancer treatment by using it to inactivate P23, a protein required for cancer growth.\u00a0 Normally, P23 is a chaperone protein aiding the heat shock protein 90 (Hsp90).\u00a0 Hsp90 has many chaperone proteins for its many different functions, and it is challenging for researchers to find a chaperone protein that will selectively target the Hsp90 implicated in a specific tumor.\u00a0 The MCG researchers believe that celastrol has the specificity to control cancer cell growth by forcing the Hsp90 to cluster together, inactivating it.<\/p>\n

\u00a0\u00a0 \u00a0\u201cCancer cells need Hsp90 more than normal cells because cancer cells have thousands of mutations.\u00a0 They need chaperones all the time to keep their mutated proteins active.\u00a0 By taking heat shock proteins away from cells, the stabilization occurs and cell death occurs,\u201d explains Dr. Chadli.<\/p>\n

\"Dr.<\/a>
Dr. Chadli researching in the laboratory.<\/figcaption><\/figure>\n

\u00a0<\/p>\n

Dr. Chadli is a researcher and professor at the Medical College of Georgia and an alumnus of the Mayo Clinic.\u00a0 He has been researching Hsp90 for over 10 years and has several works published in The Journal of Biological Chemistry <\/em>and other journals.\u00a0 He conducts thorough research to understand the intricacies of all the molecules and pathways associated with Hsp90<\/a>.\u00a0 Cancer therapy can be greatly refined with ambitious research like his.\u00a0 Dr. Chadli looks forward to future studies on cancer patients with greater dosage of celastrol, hopefully leading to greater results in the therapy.<\/p>\n

Further\u00a0information.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Sara Braniecki \u00a0\u00a0 \u00a0Dr. Ahmed Chadli and fellow researchers at the Medical College of Georgia believe that they are on the right track to finding a new cancer treatment using celastrol, a plant derivative derived from trees and shrubs called celastracaea that the Chinese have used to treat symptoms such as fever, chills, and inflammation … Continue reading Old Chinese Medicine, New Cancer Treatment<\/span><\/a><\/p>\n","protected":false},"author":271,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2073],"tags":[2087,2088,2093],"class_list":["post-31","post","type-post","status-publish","format-standard","hentry","category-disease","tag-cancer","tag-celastrol","tag-hsp90"],"_links":{"self":[{"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/posts\/31","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/users\/271"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/comments?post=31"}],"version-history":[{"count":0,"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/posts\/31\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/media?parent=31"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/categories?post=31"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.dickinson.edu\/sciencenews\/wp-json\/wp\/v2\/tags?post=31"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}