Hope for mixed-lineage leukemia’s hopeless prognosis

By Sara Braniecki

A team of researchers at University of Pennsylvania School of Medicine led by Xianxin Hua, MD, PhD, have gained detailed understanding of how mixed-lineage leukemia (MLL) fuels itself to continually cause blood cells to grow out of control.  The information, which the researchers published in he current (Feb 2010) issue of Cancer Cell, is imperative in the researchers pursuit to find an effective treatment for MLL patients in the near future.

“This research not only uncovers the crucial role of a normal protein key to the development of MLL, but also how the cancer cells stay alive in the first place,” says Hua.

MLL is an aggressive childhood cancer that occurs when a piece of chromosome 11 breaks off and attaches to a different chromosome, resulting in uncontrollable blood cell growth.  Children diagnosed with MLL poorly respond to common leukemia treatments, leaving little hope for these children.

When the piece from chromosome 11 attaches to a different chromosome, a protein is produced that leads to the uncontrollable blood cell growth that makes the children so ill.  The researchers call this protein the “fusion protein.”  The researchers deleted the gene for the normal protein from leukemia cells and the uncontrollable growth of cells did not occur, which led them to their conclusion that this normal protein was necessary for MLL to thrive.

Knockdown of normal MLL gene in human leukemia cells reduces leukemic infiltration in mouse bone marrow (left), compared with heavy leukemic infiltration in marrow from leukemia cells with normal MLL gene (right). Arrows denote leukemic cells.

Another crucial conclusion for their research is that the normal MLL protein and the “fusion proteins” interact due to chemical modifications on chromosomes.  These modifications allow a change to occur that increases the number of leukemia cells that survive over time and keeps a sufficient amount of leukemia stem cells present.

As Hua’s team of researchers continues to gain understanding of MLL they will hopefully find a better treatment for the patients afflicted with the disease.  Being diagnosed with a disease with such little hope for treatment and control is perhaps one of the most disheartening things that can happen to a child.  Hua’s team is on the right track to finding the treatment needed to give hope to children with MLL.

Further information.

256 thoughts on “Hope for mixed-lineage leukemia’s hopeless prognosis”

  12. Noida Escorts | 9311573048 | Hot Sexy Girls- PoojaEscorts
    Hello Guys, My name is Pooja. I am an Independent Girl, I love music and love to spend some time with hot boys. I am very open-minded and always looking forward to new experiences.

  13. It is safe to say that you are believing that your sexual coexistence isn’t exactly cool that you generally need? You would now be able to sprinkle your sentiments this time when you meet with the Delhi Escorts on the grounds that these young ladies are sufficiently great to ensure you’re capable for the sex and close life towards the intense things.

  15. PROMOTE Abhi is known for creating stunning websites that offer rich User Experience, increase sales, engage and convert a visitor to a customer. Bestowed with a professional team of web developers and web designers, PROMOTE Abhi is determined to give fresh and unique website designing solutions to meet various requirements and challenges posed by the clients.
    https://www.promoteabhi.com/google-ads-management

  16. jaipurskoka are the best companies to book when you want to spend time with truly amazing women. We are outstanding reputed CALL GIRLS IN JAIPUR working since last 10 years.

  18. I like reading through a post that will make people think. Also, thanks for allowing me to comment!
    We have just had those young girls who are taking a shot at their own will and are particularly certain.

  19. A very energetic article, I loved that bit, Blogs deliver a large amount of creativity. I am sure this piece of writing has touched all the internet viewers.

  21. The amount due to providers or medical billing companies for medical healthcare services is referred to as Accounts Receivable (AR). Accounts Receivable Management is a set of methods that includes determining denied/unpaid payments, re-filing corrected claims, reducing AR days, and removing aged AR.

  22. Umm al-Quwain, also known as UAQ, is an emirate in the UAE and is located in the northern part of the country. The capital of the emirate also has the same name, just like all the other emirates. UAQ is a bright location for the setting up of a new company. Being located in the north, UAQ offers easy access to prime markets of the Middle East and of Northern Africa.

  24. pdf4certs.com is the highest-rated business since they provide top-quality Oracle materials for a variety of IT certification tests. In addition, they offer a money-back warranty on their products. They do not just declare themselves to be among the best but also demonstrate this by their actions. The 1Z0-1072dumps are among their most popular. The people who use it are 1Z0-1072100% satisfied with the product. The greatest thing about it is that they don’t overload the students and make the test papers to perfection. Anyone can be successful on the first try.

  25. I like reading through a post that will make people think. Also, thanks for allowing me to comment!
    We have just had those young girls who are taking a shot at their own will and are particularly certain.
    Visit our website:-

  26. Best of luck… Reply Delete. Very good article. No doubt it will be very useful for all blogger readers. Like Google’s search using web, videos, images, books, and news just in one box from any corner of the world within seconds with fast speed internet connection.For most up-to-date information you have to pay a quick visit to this site and be up to date every day. Best Personal Wealth Management Software for Advisor in Dubai UAE

  29. I’m not shy or coy about my desire to please men and women alike – because I know exactly what both sexes want from their escorts service provider: absolute satisfaction every single time they see me!

    Hi, my name is New Sweet Asian Girl Just Arrived Here! I’m the kind of girl that will make you happy. Soft skin, beautiful face and a natural perfect body – 100% hot and 100% sexy.

  32. You might know that Delhi Escorts are famous for their beauty and their sexy body, and if you are in Delhi, you can’t miss out on that. So, don’t be alone while you are in this great city, and hire Delhi Call Girls right now to enjoy yourself with amazing Delhi Escorts. We bet that once you experience the companionship of Delhi women, you will stop thinking about anything else in life.

  34. Hi looking for any Body to body massage spa indhiranagar  then Bella spa is best option for you we are top class thai massage, female to male massage and happy ending massage provider in indhiranagar. We have top class massage therapist across many states.

  36. Alipore is a place for prominent Independent Delhi Escorts. On the off chance that you seek appropriately, you will discover a lot of bona fide Delhi Call Girls willing to take into account your escorting needs. You can discover probably the most astonishing ladies. You won’t trust your eyes when you witness these shocking women. Great looks, extraordinary identity, and astounding administrations every last bit of it is offered by Delhi Escorts. You are very fortunate if you dwell in the zone.

  37. An important message to spa lover that now get your erotic massage, naked massage in Jayanagar started by Bella spa in order to expand our customer service quality visit once and go with trust worthy body massage.

  40. Hello, gentleman are you looking for authentic Escorts in Udaipur, so you are on accurate place.** Read-Blog **
    This is our Udaipur Escorts Service internet site in this we give info of our all offerings which we offer to our clients. Our Udaipur Call ladies Agency have a totally robust base in Udaipur we make our escorts market very strong we’ve many regular customers who continually come to our company for hiring name girls in Udaipur.

  46. Hello, guys welcome to my Bio I am Ankita Sharma & I am living in Delhi (City in India). I like Delhi City and Delhi people. My age is 21 years old. My Hobbies Dancing and Modeling. And I like to add new friends. Like young boys and Girls.

Comments are closed.