By Liz H. ‘10
A promising new HIV treatment has been discovered in an unlikely source: a widely available acne medication developed in the 1970s. A team of scientists from Johns Hopkins University reports that minocyclin stops HIV-infected human cells from reactivating and replicating, in a study published in the April 15th issue of the Journal of Infectious Diseases. Their findings may lead to an improved and more effective treatment regimen for HIV infection.
The researchers focused their study on latent, non-replicating HIV-infected human T-cells. T-cells are a type white blood cell that normally fights infection. HIV infects T-cells and can “rest” inside of them for an extended period of time. The virus does not harm the T-cell during this latent phase, but can eventually “wake-up” and re-activate the T-cell, which spreads HIV infection and weakens the immune system.
In this study, the scientists treated latent HIV-infected human T-cells with minocycline and measured the level of re-activated T-cells over time. They also performed the same measurements on cells that were not treated with minocycline. The researchers found that the minocycline-treated cells did not display detectable levels of reactivation while the untreated cells displayed elevated levels.
Upon closer analysis of the activity of minocycline inside of cells, the scientists discovered that the drug interferes with important cellular communication pathways that cause the T-cell to activate and spread HIV to other cells. “It prevents the virus from escaping in the one in a million cells in which it lays dormant in a person…That’s the goal: Sustaining a latent non-infectious state,” explains Gregory Szeto, a Hopkins graduate student who worked on the project.
These findings suggest that minocycline could be used in conjunction with HAART, the current HIV treatment standard, to keep the virus dormant inside of T-cells. “While HAART is really effective in keeping down active replication, minocycline is another arm of defense against the virus,” says author Janice Clements. Minocycline is an attractive addition to the current arsenal of HIV medications because it is relatively inexpensive, does not inhibit the ability of T-cells to fight other infections, and is not likely to cause viral drug resistance.
Current treatment for HIV/AIDS involves a combination therapy approach known as HAART. Patients on HAART take at least 3 antiretroviral drugs daily that act on the virus in different ways to reduce its levels in the bloodstream. Although HAART can extend the life of an infected individual, it is not a cure and causes unpleasant side effects and the development of drug resistance. For the 40 million HIV-positive individuals worldwide, this new use for minocycline promises improved outcomes.
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Awesome! Nice Article. Very informable. Definatly will check back in. Keep up the good work!
This is what one would call ‘Recycling Science’. Amazing stuff.
At least previous studies are still usable instead of always studying new ones without finishing the former.
Nice to know that another scientist have new treatment for HIV patients. It will be good news for for HIV patients around the world.
this is a good news to those who have HIV virus. it is a great discovery
Can anyone explain the picture above. I understand the green spheres are HIV viruses and the violet is the CD4 T-cell. But what is the structure in pink/red?
This is great news. I hope this treatment is available to third world nations where the disease has been raging and killing millions
Good information collect from here. HIV is now so dangerous sick be care all time.
This is a good news to those who have HIV virus. I’m sure one day scientists will find a definitive acne cure too.
Great Collection!
thanks for sharing, I like the way that you adopted to write, excellent way of elaborating, Thanks !
yes , this is a good news to those who have HIV virus. it is a very great discovery
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i like this article, it has a lot of info i need to know, thanks for sharing
Thank you for sharing this. In fact, it is wonderful that we are moving on and still looking for solutions to huge problems like HIV. I am sure that someday this disease will be something like seasonal flu for us. At least I would really like to believe it. I am glad that we are also solving such difficult problems as the one that is facing us now, namely Covid. I’m surprised at how quickly we can develop some kind of treatment or vaccine in such an environment. This is a great achievement of science.