Tag: depression

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4 Herbal Supplements for Anxiety and Depression

Passionflower image
Passionflower; Credit: Martin Thomas, Creative Commons
Saffron flowers
Saffron flowers; Credit: Ioulrc, Creative Commons
Chaste berry
Flowering chaste-tree; Credit: Tatters, Creative Commons
Lavender; Credit: Amanda Slater, Creative Commons

 

 

 

 

 

 

 

 

 

 

 

 

 

According to a recent study, one-third of cancer patients suffer from anxiety, depression, or adjustment disorder in the months following their diagnosis. As a result, many of them add prescription anxiolytic (anti-anxiety) and antidepressant drugs to their cocktail of chemotherapy, radiation therapy, anti-coagulants, and antibiotic drugs.

The problem is that some of these anxiolytic and antidepressant drugs interact with cancer treatments and are less effective in cancer patients. They also trigger a horde of negative side effects that compound the side effects of regular cancer treatments, including seizures, headaches, and addiction.

A group of scientists at the Memorial Sloan Kettering Cancer Center in New York City decided to take a closer look at alternative herbal remedies to treat anxiety and depression in cancer patients. Research done on herbal supplements and plant extracts has been scarce, so the scientists examined a collection of studies completed between 1996 and 2016. By gathering and organizing the data, they noticed that not only are several alternative remedies helpful in ameliorating anxiety and depression, they also counteract aversive effects of chemotherapy and even combat cancer themselves. While not a perfect substitute, the following herbs have promising potential:

1. Extracts of saffron, a spice derived from a Middle Eastern flower, may be able to treat mild to moderate anxiety about as well as fluoxetine (Prozac) and imipramine (Tofranil). It has also been successful in easing anxiety and depression caused by PMS in women.

2. Lavender pills, made from oil of the lavender plant, are able to treat anxiety comparable to the drugs paroxetine (Paxil) and lorazepam (Ativan), but with fewer side effects. Lavender lotions and diffuser oils are often advertised for their calming and relaxation properties, and this holds true for lavender tea and extract drops, which may increase the efficacy of antidepressants citalopram (Celexa) and imipramine (Tofranil).

3. Passionflower, although no better than prescription drugs, seems to perform similarly but with fewer side effects, when compared to oxazepam (Serax) and sertraline (Zoloft). This substance also comes from a flower, which Native Americans have historically used to prevent insomnia.

4. Chasteberry, typically used for PMS symptoms, was compared to fluoxetine (Prozac), and while it didn’t seem to address psychological symptoms of depression, including persistent sadness, hopelessness, and loss of interest, it did alleviate physical symptoms, such as sleep trouble, digestive problems, muscle aches, and headaches.

Overall, researchers found that the herbs are not as potent, but are safer than the prescription counterparts. Clinical trials are needed to further analyze the potential of these herbal supplements and determine their benefits, especially within a oncology context. Because these supplements can be purchased over the counter, physicians don’t always know which supplements their patients are taking. It’s important to discuss an alternative treatment plan with a doctor before use.

Source:

Simon Yeung, K., Hernandez, M., Mao, J.J, Haviland, I., & Gubili, J. (2018). Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance. Phythother Res. [Epub ahead of print]. doi: 10.1002/ptr.6033

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Molecular markers identified for autism, schizophrenia, and depression

Some psychological disorders, such as schizophrenia, tend to be highly heritable, meaning that the disorder is often passed down generationally within a family. Schizophrenia, for instance, is 60-87% heritable; if you were to have schizophrenia, there’s a 60-87% chance that one of your immediate relatives will develop symptoms, too. Similarly, major depressive disorder is 30-40% heritable. Therefore, in order to treat these disorders, its necessary to look at the genes involved. A February 2018 study published in Science found that there is significant overlap in gene expression between autism spectrum disorder, schizophrenia, and bipolar disorder, as well as an overlap between schizophrenia, bipolar disorder, and major depression. The strongest relationship was between schizophrenia and autism spectrum disorder.

Consider gene expression as a construction company. A construction company has a stockpile of materials: concrete, glass, cement, wood, nails, etc. The company has a crew of workers, and the crew is capable of building a variety of houses and apartment buildings. The construction company is analogous to the use of DNA by cells in the brain. The DNA is like the stockpile of materials. The materials are required to build anything, but the possible combinations of materials are endless. The RNA transcription mechanism in the cells is like the crew. The crew chooses which materials to use, and determines how much of each item is necessary for the project. In cells, this system is called “gene expression.” Every cell in the brain has the same DNA, or the same starting materials, but each cell has a different construction crew that decides to use the materials slightly differently; some build houses, some build apartment buildings, some build garages.

Instead of examining the DNA, or the building materials in over 700 cadaver brain samples used in the study, the researchers looked at the gene products, or what the construction crews built. It is unknown whether the gene products found in the brains caused the disorder symptoms, or gradually developed throughout life as the consequence of the disorders. But the study provides useful information regarding what proteins and structural factors manifest in disordered brains, and this information can be used to trace back to an origin point. Director of the UCLA Center for Autism Research and Treatment, and author of the study Daniel Geschwind said, “These findings provide a molecular, pathological signature of these disorders, which is a large step forward.”

The scientists found biological markers that tend to distinguish a brain with autism, for example, from the average brain. In the case of autism spectrum disorder, the study reported an increased activation of the CD11 gene, while another gene called CD2 was especially active in the brains suffering from depression. Additionally, the study mapped gene expression commonalities between brains with the same disorder, essentially establishing a molecular blueprint that can be recognized for diagnosis, and treated more effectively at the molecular level.

Sources:

Gandal, M.J., Haney, J.R., Neelroop, N.P., Leppa, V., Ramaswami, G., Hartl, C., Schork, A.J., Appadurai, V., Buil, A., Werge, T.M., Liu, C., White, K.P., CommonMind Consortium, PsychENCODE Consortium, iPSYCH-BOARD Working Group, Horvath, S., & Gerchwind, D.H. 2018. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 359: 693–697.

Hopper, Leigh. 2018. Autism, schizophrenia, bipolar disorder share molecular traits, study finds. UCLA Newsroom. Retrieved Feb. 26 from http://newsroom.ucla.edu/releases/autism-schizophrenia-bipolar-disorder-share-molecular-traits-study-finds.

Seidel, D.C., Bulk, C., Stanley, M.A. 2017. Abnormal Psychology: A Scientist-Practitioner Approach (4th Edition). Pearson Education [print].

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Ketamine for Dopamine: Club Drug Cures Depression?

Recently ketamine has come under focus for its notable effects treating depression. A new study seeks to identify the pathway that allows its rapid anti-depressant effects. The horse tranquilizer turned party drug may have found another niche. The study was published in Nature, funded by the National Key R&D program of China.

As this research is in its introductory stages, researchers used a mouse model instead of human subjects. To simulate depression symptoms, rats were specifically bred as “Congenitally Learned Helpless” and mice as “Chronic Restraint Stress”. The animals were then injected with Ketamine and their behavior or electrophysiology was examined.

The findings revealed that the ketamine works by inhibiting the NMDAR pathway, nicknamed the “anti-reward center”. Burst evoking stimulation of this pathway has been show to lead to depressive behavior and anhedonia. By inhibiting the NMDAR, downstream reward centers have been shown to quickly elevate mood and produce rapid acting anti-depressant effects.

This research does not address the question of what the long-term effects of ketamine are, and its utility may lie in helping to understand the pathways that regulate depressive mood rather than paving the way for ketamine prescriptions as an antidepressant, being that it has a significant potential for abuse (not to mention a sorted reputation).

Anti-depressants tend to focus on boosting serotonin and dopamine expression to elevate mood, but by understanding and manipulating the pathway that inhibits their expression, a more targeted and effective treatment can be administered. The discovery of the NMDAR antagonist and its rapid anti-depressant effects has been called the most important advance in psychiatry in the last century. We live in an age where clinical depression has become relatively commonplace, and the recently discovered effects of Ketamine as this critical antagonist cannot be ignored.

 

Yang Y, Cui Y, Sang K, Dong Y, Ni Z et. al. (2018) Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature 554: 317-22